In 2079, in Washington, the ex-CIA Operative Snow is brutally interrogated, accused of treason against the United States. The chief of the secret service Scott Langral believes that he shot the agent Frank in a hotel room. Meanwhile, the idealistic daughter of the president of the USA, Emilie Warnock, is visiting MS One, a maximum security prison in outer space expecting to find evidences that the prisoners are actually guinea pigs of a huge corporation. When one of her bodyguards loses a hidden...

In Nazi-occupied France, young Jewish refugee Shosanna Dreyfus witnesses the slaughter of her family by Colonel Hans Landa. Narrowly escaping with her life, she plots her revenge several years later when German war hero Fredrick Zoller takes a rapid interest in her and arranges an illustrious movie premiere at the theater she now runs. With the promise of every major Nazi officer in attendance, the event catches the attention of the "Basterds", a group of Jewish-American guerrilla soldiers led...